Monday, November 19, 2012

Study finds breast cancer risk higher in some jobs

A study published in BioMed Central's Environmental Health confirms that certain occupations do pose a higher risk of breast cancer than others, particularly those that expose the worker to potential carcinogens and endocrine disrupters.

 In their study, James T Brophy and his colleagues set out to characterize the possible links between breast cancer and occupation, particularly in manufacturing and farming.

The study was conducted in Southern Ontario, Canada, and included 1006 breast cancer cases with 1147 randomly selected and matched community controls. Using interviews and surveys, the team collected data on participants' occupational and reproductive histories. All jobs were coded for their likelihood of exposure to carcinogens and endocrine disruptors, and patients' tumor pathology regarding endocrine receptor status was assessed.

The authors found in this group of participants that, across all sectors, women in jobs with potentially high exposures to carcinogens and endocrine disrupters had an elevated breast cancer risk. Sectors with increased risk included:
  • Agriculture
  • Bar/gambling
  • Automotive plastics manufacturing
  • Food canning and metal-working
Importantly, pre-menopausal breast cancer risk was highest in the automotive plastics and food canning industries.

The findings also suggested that women with lower socioeconomic status had an elevated risk of breast cancer, which may result from higher exposures to endocrine-disrupting chemicals in the lower-income manufacturing and agricultural industries of the study area.

"Our results highlight the importance of occupational studies in identifying and quantifying environmental risk factors and illustrates the value of taking detailed occupational histories of cancer patients. Mounting evidence suggests that we need to re-evaluate occupational exposure limits in regulatory protection," said Brophy.

Breast cancer is the most frequent cancer diagnosis among women in industrialized countries, and North American rates are among the highest in the world.


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